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1

Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells

Jürgen Jacob, Gottfried Raab, Volker Soballa, Wolfgang A. Schmalix, Gernot Grimmer, Helmut Greim, Johannes Doehmer, Albrecht Seidel

Journal:

Environmental Toxicology and Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1.16 MB

english, 1996

2

Assessment of a dry extract from milk thistle (Silybum marianum) for interference with human liver cytochrome-P450 activities

Johannes Doehmer, Gabriele Weiss, Gerard P. McGregor, Kurt Appel

Journal:

Toxicology in Vitro

Année:

2011

Langue:

english

Fichier:

PDF, 554 KB

english, 2011

3

Mutations induced by (−)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells

Brinda Mahadevan, Wan-Mohaiza Dashwood, Andreas Luch, Arta Pecaj, Johannes Doehmer, Albrecht Seidel, Cliff Pereira, William M. Baird

Journal:

Environmental and Molecular Mutagenesis

Année:

2003

Langue:

english

Fichier:

PDF, 136 KB

english, 2003

4

Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar

Brinda Mahadevan, Charis P. Marston, Andreas Luch, Wan-Mohaiza Dashwood, Eric Brooks, Cliff Pereira, Johannes Doehmer, William M. Baird

Journal:

International Journal of Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 377 KB

english, 2007

5

Enhanced expression of the proto-oncogenes fos and raf in the rhabdomyosarcoma cell line BA-HAN-1C after differentiation induction with retinoic acid and N-methylformamide

N. E. Gabbert, C.- D. Gerharz, U. Ramp, J. Hoffmann, O. Oster, F. Oesch, J. Doehmer

Journal:

International Journal of Cancer

Année:

1990

Langue:

english

Fichier:

PDF, 1010 KB

english, 1990

6

Stable expression of rat cytochrome P450IA2 cDNA and hydroxylation of 17β-estradiol and 2-aminofluorene in V79 Chinese hamster cells

Catherine Wölfel, Karl-Ludwig Platt, Satish Dogra, Hansruedi Glatt, Felix Wächter, Johannes Doehmer

Journal:

Molecular Carcinogenesis

Année:

1991

Langue:

english

Fichier:

PDF, 820 KB

english, 1991

7

Biotransformation of methylxanthines in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Allocation of metabolic pathways to isoforms and inhibitory effects of quinolones

Uwe Fuhr, Johannes Doehmer, Narayana Battula, Catherine Wölfel, Ingrid Flick, Christine Kudla, Yango Keita, A.Horst Staib

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 1.24 MB

english, 1993

8

V79 Chinese hamster cells genetically engineered for cytochrome P450 and their use in mutagenicity and metabolism studies

Johannes Doehmer

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 1.69 MB

english, 1993

9

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Antony Boyce, Johannes Doehmer, Nigel J. Gooderham

Journal:

Journal of Chromatography B

Année:

2004

Langue:

english

Fichier:

PDF, 108 KB

english, 2004

10

Territrems B and C metabolism in human liver microsomes: Major role of CYP3A4 and CYP3A5

Fu-Chuo Peng, Chiao-Chia Chang, Ching-Yao Yang, Robert J. Edwards, Johannes Doehmer

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 404 KB

english, 2006

11

CYP2D6 increases toxicity of the designer drug 4-methylthioamphetamine (4-MTA)

Helena Carmo, Marc Brulport, Matthias Hermes, Franz Oesch, Douwe de Boer, Fernando Remião, Félix Carvalho, Michael R. Schön, Niels Krebsfaenger, Johannes Doehmer, Maria de Lourdes Bastos, Jan G. Hengs

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 517 KB

english, 2007

12

The phytoalexin resveratrol attenuates 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced mutagenicity in mammalian cells

A.P. Boyce, J. Price, J. Doehmer, N.J. Gooderham

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 171 KB

english, 2000

13

Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines

Alan J Townsend, Sandra L Kabler, Johannes Doehmer, Charles S Morrow

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 206 KB

english, 2002

14

Assessment of Extracts from Mistletoe (Viscum album) for Herb–Drug Interaction by Inhibition and Induction of Cytochrome P450 Activities

Johannes Doehmer, Jürgen Eisenbraun

Journal:

Phytotherapy Research

Année:

2012

Langue:

english

Fichier:

PDF, 256 KB

english, 2012

15

Cytochromes P450 and drug resistance

Johannes Doehmer, Arnold R. Goeptar, Nico P. E. Vermeulen

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 624 KB

english, 1993

16

Uniform response of c-raf expression to differentiation induction and inhibition of proliferation in a rat rhabdomyosarcoma cell line

U. Ramp, C. D. Gerharz, J. Doehmer, O. Oster, H. E. Gabbert

Journal:

Virchows Archiv B Cell Pathology Zell-pathologie

Année:

1990

Langue:

english

Fichier:

PDF, 2.82 MB

english, 1990

17

Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity

Alexandra Westerholt, Sigrid Himpel, Birgit Hager-Gensch, Stefan Maier, Martin Werner, Josef Stadler, Johannes Doehmer, Claus-Dieter Heidecke

Journal:

Transplant International

Année:

2004

Langue:

english

Fichier:

PDF, 271 KB

english, 2004

18

Use of V79 cells with stably transfected cytochrome P450 cDNAs in studying the metabolism and effects of cytotoxic drugs

Philip Agop Philip, Shadan Ali-Sadat, Johannes Doehmer, Thomas Kocarek, Aftab Akhtar, Hong Lu, Kenneth K. Chan

Journal:

Cancer Chemotherapy and Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 384 KB

english, 1999

19

Intragraft iNOS induction during human liver allograft rejection depresses cytochrome p450 activity

Alexandra Westerholt, Sigrid Himpel, Birgit Hager-Gensch, Stefan Maier, Martin Werner, Josef Stadler, Johannes Doehmer, Claus-Dieter Heidecke

Journal:

Transplant International

Année:

2004

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2004

20

The potential of acetaminophen as a prodrug in gene-directed enzyme prodrug therapy

Thatcher, Natalie J, Edwards, Robert J, Lemoine, Nicholas R, Doehmer, Johannes, Davies, Donald S

Journal:

Cancer Gene Therapy

Année:

2000

Langue:

english

Fichier:

PDF, 143 KB

english, 2000

21

Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using Chinese hamster x mouse somatic cell hybrids

R. Schäfer, J. Doehmer, I. Rademacher, K. Willecke

Journal:

Somatic Cell and Molecular Genetics

Année:

1980

Langue:

english

Fichier:

PDF, 678 KB

english, 1980

22

The cytotoxicity of mitomycin C and Adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes

Arnold R. Goeptar, Johan M. te Koppele, Hansruedi R. Glatt, Ed J. Groot, Albrecht Seidel, Martine Barrenscheen, Catherine Wölfel, Johannes Doehmer, Nico P.E. Vermeulen

Journal:

Chemico-Biological Interactions

Année:

1995

Langue:

english

Fichier:

PDF, 1.53 MB

english, 1995

23

Transfection and stable expression of genes encoding xenobiotic-metabolizing enzymes in V79 cells

H.R. Glatt, S. Dogra, C. Janssens, J. Doehmer, F. Oesch

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1991

Langue:

english

Fichier:

PDF, 171 KB

english, 1991

24

V79 cells genetically engineered for stable expression of cytochromes P-450

J. Doehmer, F. Oesch, C. Janssens, M. Edigkaufer, M. Barrenscheen, H.-R. Glatt, A. Seidel, K. Platt

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1992

Langue:

english

Fichier:

PDF, 87 KB

english, 1992

25

Sequence of the rat PB-inducible CYP2B1 promoter

Peter Martin Shaw, Michael Edigkaufer, Johannes Doehmer, Milton Adesnik

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Année:

1996

Langue:

english

Fichier:

PDF, 393 KB

english, 1996

26

On the species-specific biotransformation of dibenzo[a,l]pyrene

Wolfgang Schober, Andreas Luch, Volker J. Soballa, Gottfried Raab, John J. Stegeman, Johannes Doehmer, Jürgen Jacob, Albrecht Seidel

Journal:

Chemico-Biological Interactions

Année:

2006

Langue:

english

Fichier:

PDF, 629 KB

english, 2006

27

Differential protection by human glutathione S-transferase P1 against cytotoxicity of benzo[a]pyrene, dibenzo[a,l]pyrene, or their dihydrodiol metabolites, in bi-transgenic cell lines that co-express rat versus human cytochrome P4501A1

Sandra L. Kabler, Albrecht Seidel, Juergen Jacob, Johannes Doehmer, Charles S. Morrow, Alan J. Townsend

Journal:

Chemico-Biological Interactions

Année:

2009

Langue:

english

Fichier:

PDF, 267 KB

english, 2009

28

Cytotoxicity and mutagenicity of dibenzo[a,l]pyrene and (±)-dibenzo[a,l]pyrene-11,12-dihydrodiol in V79MZ cells co-expressing either hCYP1A1 or hCYP1B1 together with human glutathione-S-transferase A1

Mary E. Kushman, Sandra L. Kabler, Sarfaraz Ahmad, Johannes Doehmer, Charles S. Morrow, Alan J. Townsend

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2007

Langue:

english

Fichier:

PDF, 273 KB

english, 2007

29

Assessment of extracts from mistletoe (Viscum album) for herb–drug interaction by inhibition and induction of cytochrome P450 activities

J. Doehmer, J. Eisenbraun

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 56 KB

english, 2011

30

Cytochrome P450 CYP1B1 protein expression:: A novel mechanism of anticancer drug resistance

Morag C.E McFadyen, Howard L McLeod, Fiona C Jackson, William T Melvin, Johannes Doehmer, Graeme I Murray

Journal:

Biochemical Pharmacology

Année:

2001

Langue:

english

Fichier:

PDF, 155 KB

english, 2001

31

Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection

Alan J Townsend, Wanda R Fields, Robin L Haynes, Amanda J Doss, Ying Li, Johannes Doehmer, Charles S Morrow

Journal:

Chemico-Biological Interactions

Année:

1998

Langue:

english

Fichier:

PDF, 190 KB

english, 1998

32

Molecular analysis of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mutation in the hprt gene

M. Yadollahi-Farsani, N.J. Gooderham, J. Doehmer, D.S. Davies, A.R. Boobis

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Année:

1996

Langue:

english

Fichier:

PDF, 180 KB

english, 1996

33

Kinetics and Inhibition by Fluvoxamine of Phenacetin O-Deethylation in V79 Cells Expressing Human CYP1A2

Klaus Gjervig Jensen, Henrik Enghusen Poulsen, Johannes Doehmer, Steffen Loft

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1995

Langue:

english

Fichier:

PDF, 231 KB

english, 1995

34

Paracetamol-Induced Spindle Disturbances in V79 Cells with and without Expression of Human CYP1A2

Klaus Gjervig Jensen, Henrik Enghusen Poulsen, Johannes Doehmer, Steffen Loft

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

1996

Langue:

english

Fichier:

PDF, 514 KB

english, 1996

35

The Use of Macroporous Microcarriers for the Large-Scale Growth of V79 Cells Genetically Designed to Express Single Human Cytochrome P450 Isoenzymes and for the Characterization of the Expressed Cytochrome P450

Rob C.A. Onderwater, Arnold R. Goeptar, Piet R. Levering, Ria M.E. Vos, Pierre N.M. Konings, Johannes Doehmer, Jan N.M. Commandeur, Nico P.E. Vermeulen

Journal:

Protein Expression and Purification

Année:

1996

Langue:

english

Fichier:

PDF, 161 KB

english, 1996

36

Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms

Uwe fuhr, Johannes Doehmer, Narayana Battula, Catherine Wölfel, Christine Kudla, Yango Keita, A.Horst Staib

Journal:

Biochemical Pharmacology

Année:

1992

Langue:

english

Fichier:

PDF, 1.03 MB

english, 1992

37

Metabolism of phenacetin in V79 Chinese hamster cell cultures expressing rat liver cytochrome P4501A2 compared to isolated rat hepatocytes

Klaus Gjervig Jensen, Steffen Loft, Johannes Doehmer, Henrik E. Poulsen

Journal:

Biochemical Pharmacology

Année:

1993

Langue:

english

Fichier:

PDF, 409 KB

english, 1993

38

Assessment of drug–drug interaction for silymarin

Johannes Doehmer, Bernhard Tewes, Kai-Uwe Klein, Kristin Gritzko, Holger Muschick, Ulrich Mengs

Journal:

Toxicology in Vitro

Année:

2008

Langue:

english

Fichier:

PDF, 218 KB

english, 2008

39

Stable expression of human inducible nitric oxide synthase in V79 Chinese hamster cells

Wolfgang A. Schmalix, J.Jasuvant Singh, Peter Kapfhammer, Josef Stadier, Andreas K. Nüssler, David A. Geller, Timothry R. Billiar, Richard L. Simmons, Helmut Greim, Johannes Doehmer

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1.30 MB

english, 1996

40

Caffeine metabolism by microsomal and cDNA-expressed cytochrome P450 1A from scup (Stenotomus chrysops)

B.R. Woodin, J. Doehmer, J.J. Stegeman

Journal:

Marine Environmental Research

Année:

2000

Langue:

english

Fichier:

PDF, 45 KB

english, 2000

41

Catalytic properties of scup cytochrome P4501A expressed in Chinese hamster V79 cells

J.J. Stegeman, V. Soballa, H.G. Morrison, J. Jacob, J. Doehmer

Journal:

Marine Environmental Research

Année:

1998

Langue:

english

Fichier:

PDF, 94 KB

english, 1998

42

Cell culture system for the controlled intracellular generation of reactive oxygen species

H. Hermersdörfer, B. Ozierenski, W.A. Schmalix, J. Doehmer, H.R. Glatt

Journal:

Toxicology in Vitro

Année:

1997

Langue:

english

Fichier:

PDF, 368 KB

english, 1997

43

Improved Determination of Drug Metabolism by Perifusion of Recombinant V79 Cells Carrying Human CYP3A4

R Gebhardt, C Lippert, A Schneider, J Doehmer

Journal:

Toxicology in Vitro

Année:

1999

Langue:

english

Fichier:

PDF, 104 KB

english, 1999

44

Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450

Albrecht Seidel, Volker J Soballa, Gottfried Raab, Heinz Frank, Helmut Greim, Gernot Grimmer, Jürgen Jacob, Johannes Doehmer

Journal:

Environmental Toxicology and Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 277 KB

english, 1998

45

Induction of rat brain and liver cytochrome P450 1A1/1A2 and 2B1/2B2 isoenzymes by deltamethrin

Monika Dayal, Devendra Parmar, Alok Dhawan, Uppendra N Dwivedi, Johannes Doehmer, Prahlad K Seth

Journal:

Environmental Toxicology and Pharmacology

Année:

1999

Langue:

english

Fichier:

PDF, 264 KB

english, 1999

46

Inhibition of biotransformation by nitric oxide (NO) overproduction and toxic consequences

Josef Stadler, Wolfgang A. Schmalix, Johannes Doehmer

Journal:

Toxicology Letters

Année:

1995

Langue:

english

Fichier:

PDF, 495 KB

english, 1995

47

Genetically engineered mammalian cells and applications

Johannes Doehmer, Anneliese Schneider, Markus Faβbender, Volker Soballa, Wolfgang A. Schmalix, Helmut Greim

Journal:

Toxicology Letters

Année:

1995

Langue:

english

Fichier:

PDF, 498 KB

english, 1995

48

Fusion with mouse thymocytes leads to expression of p30 antigen in fibroblasts of BALB/Mo mice

Johannes Doehmer, Ingeborg Rademacher, Klaus Willecke

Journal:

Année:

1980

Langue:

english

Fichier:

PDF, 317 KB

english, 1980

49

Genetically engineered cells for drug metabolism studies: Advantages and limitations

Journal:

Pharmacological Research

Année:

1995

Langue:

english

Fichier:

PDF, 139 KB

english, 1995

50

Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (“ecstasy”) cytotoxicity

H. Carmo, M. Brulport, M. Hermes, F. Oesch, R. Silva, L.M. Ferreira, P. Branco, D. de Boer, F. Remião, F. Carvalho, M.R. Schön, N. Krebsfaenger, J. Doehmer, M.L. Bastos, J.G. Hengstler

Journal:

Toxicology Letters

Année:

2006

Langue:

english

Fichier:

PDF, 101 KB

english, 2006